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NEWS1.Pepsinogen
Pepsinogen (PG) is the precursor of pepsin secreted by the stomach and involved in digestion. Generally, 1% of PG can enter the blood circulation through the gastric mucosa, which can be divided into two subtypes: PGI and PGII
Serum pepsinogen can accurately show the state and function of gastric mucosa
Pepsinogen I is secreted by the main cells and cervical mucus cells of the gastric fundus gland
Pepsinogen II can be produced in the pyloric and duodenal glands in addition to the secretion of the host cells and cervical mucus cells
2.Biological Function Of Pepsinogen
With the development of gastric disease, PGI in serum first increases, then decreases, and then increases, and then maintains a higher level. Thus, the abnormal PGI / PGII ratio of PGI and PGII will indicate the different course of gastric disease and become the primary screening index and monitoring index of treatment for gastric diseases
3.Main Clinical Significance
A. Early screening of gastric cancer
B. Screening of gastric ulcer, atrophic gastritis and HP infection
C. Evaluation of therapeutic effect of Helicobacter pylori (HP)
D. Criteria for recurrence and cure of peptic ulcer
E. Criteria of recurrence after gastrectomy
F. Dynamic examination of gastric mucosa function
4.Who is suitable for PGI / PGII
Helicobacter pylori infection
Male, especially over 2025kg
50 to 80
Salt, pickled vegetables, bacon and fish
Smoke
Old stomach with gastric operation and polyp
Family cancer, family history of gastric cancer
Pernicious anemia
Type A blood
Long term working with a lot of smoke, asbestos and nickel ring
5.Reference Norm
PGI normal reference value range is 70-200ng / ml
PGII normal reference value range is 0-15ng / ml
PGI/ PGII7.5
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